Cover Feature: Theoretical Studies of Mutual Effects between 6‐m‐r Hemiketalization and 26‐m‐r Lactonization in Pimaricin Thioesterase (Chem. Asian J. 7/2023)
نویسندگان
چکیده
Cooperation between 6-m-r hemiketalization and 26-m-r macrolactonization is reported for a thioesterase (pimTE) in type-I polyketide synthase. Intriguingly, the R-hemiketal intermediate not only catalyzed by D179 residue, but also twists substrate hairpin structure to lactonizing pre-reaction state. Thus, pimTE believed be bifunctional enzyme, which can synergistically catalyze tandem formations during main-chain release of pimaricin biosynthesis. More information on this study found Research Article Linquan Bai, Yi-Lei Zhao et al.
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ژورنال
عنوان ژورنال: Chemistry-an Asian Journal
سال: 2023
ISSN: ['1861-471X', '1861-4728']
DOI: https://doi.org/10.1002/asia.202300133